2025

  1. Akiko Fujii, Kwihwan Kobayashi, Tomoki Hyodo, Tsuyoshi Yamada, Takashi Ikawa, Hironao Sajiki
    Synthesis of Functionalized Cyclic Ethers via Gold-Catalyzed Cyclization and Rearrangement
    Adv. Synth. Catal., inpress
    https://doi.org/10.1002/adsc.70012
  2. Naoya Sakurada, Kanon Kawai, Yuka Abe, Kwihwan Kobayashi, Shinya Mine, Noriko Miyamoto, Tsuyoshi Yamada, Takashi Ikawa, Hironao Sajiki
    Durable Heterogeneous Pd-PNP Pincer Complex for Carbon-Carbon Bond Formation in Continuous-Flow Systems
    ChemSusChem, e202501205
    https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cssc.202501205
    フロー式 Mizoroki–Heck 反応で 14 日連続の高変換を実証 ― PNPリガンドと塩基最適化でPd触媒活性の維持に成功 ― | 岐阜薬科大学 創薬化学大講座 アドバンストケミストリー研究室 （解説）
    【研究成果】フロー式 Mizoroki-Heck 反応で 14 日連続の高変換を実証 ― PNPリガンドと塩基最適化でPd触媒活性の維持に成功 ―｜岐阜薬科大学（大学Webサイト）
  3. Akiko Fujii, Tomoki Hyodo, Tsuyoshi Yamada, Takashi Ikawa, Hironao Sajiki
    Silver-Catalyzed Synthesis of Isoquinolones via Oxazole Ring OpeningClick to copy article link
    J. Org. Chem. 2025, inpress
    https://pubs.acs.org/doi/10.1021/acs.joc.5c01059
  4. Sakurada, Naoya; Sasaki, Daiki; Ono, Manato; Yamada, Tsuyoshi; Ikawa, Takashi;* Sajiki, Hironao*
    Development of Site- and Stereoselective Continuous Flow Deuterium Labelling Method for Carbohydrates Using High Dispersion Effect towards Ru/C of Hydrogen Flow
    Reaction Chemistry & Engineering 2025,10, 777-781.
    https://doi.org/10.1039/D5RE00026B
    位置・立体選択的に糖を重水素化するフロー合成法を確立 ― Ru/C 触媒カートリッジで 150 時間以上の連続運転を実証 ― （解説）
    【研究成果】位置・立体選択的に糖を重水素化するフロー合成法を確立 ― Ru/C 触媒カートリッジで 150 時間以上の連続運転を実証 ―｜岐阜薬科大学　（大学Webサイト）
    位置・立体選択的に糖を重水素化するフロー合成法を確立 ― Ru/C触媒カートリッジで150時間以上の連続運転を実証 ― | Chem-Station (ケムステ)
  5. Yuka Abe, Tsuyoshi Yamada,* Takuhei Yamamoto, Yukihiro Esaka, Takashi Ikawa, Hironao Sajiki*
    Electrochemically assisted deprotection of acetals, ketals, and dithioacetals under neutral conditions
    Green Chemistry 2025, 27, 5464-5470.
    https://doi.org/10.1039/D4GC06348A
    Selected as a Cover Picture
  6. Shogo Moriyama , Yuto Emi , Toshifumi Nosaki , Yuki Morikawa , Takashi Shigeta  , Akira Takagi , Masahiro Egi  , Takashi Ikawa , Yoshinari Sawama  , Shuji Akai
    Total synthesis of aloin via regioselective Diels–Alder reactions connecting two 3-silylbenzynes and 2-stannylfuran
    Synlett 2025, 36(10), 1413-1417.
    https://doi.org/ 10.1055/a-2542-3481
  7. Hikaru Tanaka, Takashi Ikawa, Hironao Sajiki, Masanori Tachikawa, Taro Udagawa*
    Theoretical analysis of the reaction mechanism of D2 gas generation using a Pd/C catalyst
    Catalysis Science & Technology 2025, 15, 1434-1438.
    https://doi.org/10.1039/D4CY01537A

2024

  1. Sakurada, Naoya; Kobayashi, Kwihwan; Abe; Yuka; Niwa, Kosuke; Yokoyama, Takashi; Yamada, Tsuyoshi; Ikawa, Takashi; Sajiki, Hironao
    Stable and Versatile Pd Precursors for the Preparation of Robust Pd Catalysts under Continuous-Flow
    ChemSusChem 2024, e202401859.
    https://doi.org/10.1002/cssc.202401859
    Selected as a Cover Picture
    多様な材料に効率的にパラジウムを担持可能な前駆体（Pd-80）の開発と、持続的フロー触媒の創製（解説）
    【研究成果】多様な材料に効率的にパラジウムを担持可能な前駆体（Pd-80）の開発と、持続的フロー触媒の創製（大学Webサイト）
  2. Sakurada, Naoya; Kitazono, Takanori; Ikawa, Takashi; Yamada, Tsuyoshi; Sajiki, Hironao*
    Pt/CB-Catalyzed Chemoselective Hydrogenation Using in situ-Generated Hydrogen by Microwave Mediated Dehydrogenation of Methylcyclohexane under Continuous-Flow Conditions
    Catalysts 2024, 14, 384.
    https://doi.org/10.3390/catal14060384
    Selected as a Hilight paper on the main page of Catalysts
  3. Yamada, Tsuyoshi; Fujii Akiko; Furugen, Chikara; Kobayashi, Kwihwan; Hyodo, Tomoki; Ikawa, Takashi; Sajiki, Hironao*
    Gold-Catalyzed Synthesis of Ortho-Quinone Methide Analogues as Reactive Synthetic Precursors
    Adv. Synth. Catal. 2024, 366, 2270–2276.
    https://doi.org/10.1002/adsc.202400428
    Selected as a Front Cover Picture (Adv. Synth. Catal. 2024, 366, 2141).
  4. Ishida, Moeka; Adachi, Rina; Kobayashi, Kazuki; Yamamoto, Yukiko; Kawahara, Chinatsu; Yamada, Tsuyoshi; Aoyama, Hiroshi; Kanomata, Kyohei; Akai, Shuji; Lam, Patrick Y. S.; Sajiki, Hironao; Ikawa, Takashi*
    First atroposelective Chan–Lam coupling for the synthesis of C–N linked biaryls
    Chem. Commun. 2024, 60, 621–768.
    https://doi.org/10.1039/D3CC05447K
    Selected as an inside front cover
    【研究成果】世界初のアトロプ選択的Chan-Lamカップリングを開発しました！｜岐阜薬科大学

2023

  1. Maekawa, Kazuki; Ishizawa, Michiyasu; Ikawa, Takashi; Sajiki, Hironao; Matsumoto, Taro; Tokiwa, Hiroaki; Makishima, Makoto; Yamada, Sachiko*
    Syntheses of 25-Adamantyl-25-alkyl-1α,25-dihydroxyvitamin D3 Derivatives and Structure-Function Studies of ntagonistic and Agonistic Active Vitamin D Analogs
    Biomolecules 2023, 13, 1082.
    https://doi.org/10.3390/biom13071082
  2. Yamada, Tsuyoshi; Teranishi, Wataru; Sakurada, Naoya; Ootori, Seiya; Abe, Yuka; Matsuo, Tomohiro; Morii, Yasuharu; Yoshimura, Masatoshi; Yoshimura, Takeo; Ikawa, Takashi; Sajiki, Hironao*
    Microwave-assisted C–C bond formation of diarylacetylenes and aromatic hydrocarbons on carbon beads under continuous-flow conditions
    Commun. Chem. 2023, 6, 78.
    https://doi.org/10.1038/s42004-023-00880-y
    【研究成果】マイクロ波のエネルギーを利用して、クリーンな多環芳香族化合物の連続フロー合成法を開発！｜岐阜薬科大学

2022

  1. Horino, Satoshi; Nishio, Tomoya; Kawanishi, Shinji; Oki, Shinya; Nishihara, Kouichi; Ikawa, Takashi; Kanomata, Kyohei; Wagner, Karla; Gröger, Harald; Akai, Shuji
    Enantiodivergent Chemoenzymatic Dynamic Kinetic Resolution: Conversion of Racemic Propargyl Alcohols into Both Enantiomers
    Chem. Eur. J. 2022, 28, e202202437.
    https://doi.org/10.1002/chem.202202437
  2. Park, Kwihwan; Furusato, Shinichi; Furugen, Chikara; Ikawa, Takashi; Yamada, Tsuyoshi; Sajiki, Hironao
    Highly Selective Synthesis of cis-2,2,4,4-Tetramethylcyclobutane-1,3-diol via Solvent-Free Hydrogenation and Isomerization
    Asian J. Chem. 2022, 11, e202200263.
    https://doi.org/10.1002/ajoc.202200263
  3. Oka, Naoki; Yamada, Tsuyoshi; Sajiki, Hironao; Akai, Shuji;* Ikawa, Takashi*
    Aryl Boronic Esters Are Stable on Silica Gel and Reactive under Suzuki–Miyaura Coupling Conditions
    Org. Lett. 2022, 24, 3510−3514.
    https://pubs.acs.org/doi/10.1021/acs.orglett.2c01174
    【研究成果】誰でも簡単に扱えるボロン酸誘導体を開発しました！｜岐阜薬科大学
    Selected as a Supplementary Cover Art
    Most Read Articles in 30 days (Ranked in No.1). 2022/07/11
    Most Read Articles in 12 months (Ranked in No.1).2022/07/11-2022/12/18
    The most read #OrgLett articles for 2022.
    Highlighted in Chem-Station (https://www.chem-station.com/blog/2022/07/smc.html)
    Highlighted in Faculty Opinions
    (https://doi.org/10.3410/f.742220886.793594018)
    Highlighted in Synfacts
    SYNFACTS Contributors: Oestreich, Martin; Klare, Hendrik F. T.; Finck, Lucie
    Take Et instead of Me: Preparation and Application of a Novel Class of Stable Arylboronic Esters
    Synfacts 2022, 18(08), 0867. Selected as “Synfact of the month”
    https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0041-1738238
    Highlighted in Organic Process Reseach & Development, 2022, 26, 3181–3189.
    “ARYLBORONIC ESTERS ARE STABLE ON SILICA GEL AND REACTIVE UNDER SUZUKI−MIYAURA COUPLING CONDITIONS”
    Highlighted in Organic Chemistry Portal (https://www.organic-chemistry.org/abstracts/lit8/448.shtm).
    Attention Score 112 (2022/12/18)
    In the top 5% of all research outputs scored by Altmetric
    One of the highest-scoring outputs from this source (#8 of 14,044)
    High Attention Score compared to outputs of the same age (higher than 97% of its contemporaries)
    High Attention Score compared to outputs of the same age and source (#1 of 236 output, higher than 99% of its contemporaties)
    日本の研究.com
    https://research-er.jp/articles/view/110906
    The most cited tweet from 2022 on @Boron_chemistry
  4. Park, Kwihwan;* Oka, Naoki; Sawama, Yoshinari; Ikawa, Takashi; Yamada, Tsuyoshi; Sajiki, Hironao
    Platinum on carbon-catalysed site-selective H–D exchange reaction of allylic alcohols using alkyl amines as a hydrogen source
    Org. Chem. Front. 2022, 9, 1986–1991.
    https://doi.org/10.1039/D2QO00177B
  5. Yamada, Tsuyoshi* Fujii, Akiko; Park, Kwihwan; Furugen, Chikara; Takagi, Akira; Ikawa, Takashi; Sajiki Hironao*
    Catalytic Intramolecular Cyclization of Alkynyl Cyclic Acetals via Chemoselective Activation Leading to Phenanthrene Core
    Bull. Chem. Soc. Jpn. 2022, 95, 735−742.
    https://doi.org/10.1246/bcsj.20220036

2021

  1. Ikawa, Takashi;* Yamamoto, Yuta; Heguri, Akito; Fukumoto, Yutaka; Murakami, Tomonari; Takagi, Akira; Masuda, Yuto; Yahata, Kenzo; Yahata, Kenzo; Aoyama, Hiroshi; Shigeta, Yasuteru; Tokiwa,Hiroaki;* Akai; Shuji*
    Could London Dispersion Force Control Regioselective (2+2) Cyclodimerizations of Benzynes? YES: Application to the Synthesis of Helical Biphenylenes
    J. Am. Chem. Soc. 2021, 143, 10853−10859.
    https://pubs.acs.org/doi/10.1021/jacs.1c05434
    【研究成果】"弱い引力"を利用して『らせん分子』の合成に成功！｜岐阜薬科大学
    Selected as a Supplementary Cover Art
    Highlighted in Chem-Station (https://www.chem-station.com/blog/2021/08/london.html)
    Highlighted in Synfacts
    SYNFACTS Contributors: Swager, Timothy M.; Chen, Michelle
    May the 'London Dispersion Force' Be with You
    Synfacts 2021, 17(09), 0981.
    https://doi.org/10.1055/s-0040-1720812
    Highlighted in ファルマシア Editor’s Eye
    ロンドン分散力による分子構造の制御
    ファルマシアVol. 57, No. 12, 2021, 1075.
  2. Hori, Shuhei; Ishida, Sho; Itoh, Go; Egi, Masahiro; Yahata, Kenzo; Ikawa, Takashi; Akai, Shuji*
    Synthetic studies on viridin skeleton through regio- and stereoselective unctionalization of the AE-ring moiety
    Synlett 2021, 32, 1187−1191.
    https://doi.org/10.1055/a-1527-3781
  3. Saito, Kazuyuki; Zhou, Wang; Sato, Shohei; Takubo, Keita; Furutsu, Kazunori; Mohamed, Ahmed A.B.; Purwati, Euis Maras; Ikawa, Takashi; Akai, Shuji*
    Regio-Complementary Preparation of 6- and 7-Fluoro-1,2,3,4-tetrahydroquinolines via the Cyclization of Catecholamines Followed by Deoxyfluorination
    Heterocycles 2021, 103, 902−917.
    https://doi.org/10.3987/COM-20-S(K)56
  4. Tsuchimochi, Izuru; Hori, Shuhei; Takeuchi, Yasuo; Egi, Masahiro; Satoh, Tomo-o; Kanomata, Kyohei; Ikawa, Takashi; Akai, Shuji*
    Four-step one-pot catalytic asymmetric synthesis of multisubstituted tricyclic compounds: Lipase-catalyzed dynamic kinetic resolution followed by an intramolecular Diels–Alder reaction
    Synlett 2021, 32, 822-828.
    https://doi.org/10.1055/a-1344-8713

2020

  1. Ikawa, Takashi;* JingKai, Sun; Takagi, Akira; Akai, Shuji*
    One-Pot Generation of Functionalized Benzynes from Commercially Available 2-Hydroxyphenylboronic Acids
    J. Org. Chem. 2020, 85, 3383−3392.
    https://pubs.acs.org/doi/10.1021/acs.joc.9b03169
  2. Ikawa, Takashi;* Masuda, Shigeaki; Akai, Shuji*
    One-Pot Generation of Benzynes from Phenols: Formation of Primary Anilines by the Deoxyamination of Phenols
    Chem. Eur. J. 2020, 26, 4320–4332.
    Featured in Org. Chem. Highlights: Substituted Benzenes
    https://www.organic-chemistry.org/Highlights/2020/12October.shtm
    https://doi.org/10.1002/chem.201904987

2018

  1. Ikawa, Takashi;* Masuda, Shigeaki; Akai, Shuji*
    Microflow Fluorinations of Benzynes: Efficient Synthesis of Fluoroaromatic Compounds
    Chem. Pharm. Bull. 2018, 66, 1153–1164.
    Highlighted Paper selected by Editor-in-Chief
    https://doi.org/10.1248/cpb.c18-00578
  2. Kaneko, Hideki; Ikawa, Takashi;* Yamamoto, Yuta; Arulmozhiraja, Sundaram; Tokiwa, Hiroaki; Akai, Shuji*
    3-(Triflyloxy)benzynes Enable the Regiocontrolled Cycloaddition of Cyclic Ureas to Synthesize 1,4-Benzodiazepine Derivatives
    Synlett 2018, 29, 943–948.
    https://doi.org/10.1055/s-0036-1591924
  3. Iwao, Yasunori;* Tomiguchi, Izumi; Domura, Ayaka; Mantaira, Yusuke; Minami, Akira; Suzuki, Takashi; Ikawa, Takashi; Kimura, Shin-ichiro; Itai, Shigeru
    Inflamed site-specific drug delivery system based on the interaction of human serum albumin nanoparticles with myeloperoxidase in a murine model of experimental colitis.
    Eur. J. Pharm. Biopharm. 2018, 125, 141–147.
    https://doi.org/10.1016/j.ejpb.2018.01.016
  4. Ikawa, Takashi;* Sumii, Yuta; Wang, Ding; Emi, Yuto; Takagi, Akira; Masuda, Shigeaki; Akai, Shuji*
    Synthesis of Optically Active 2,3-Disubstituted Indoline Derivatives via Cycloaddition Reactions between Benzynes and α,β-Unsaturated-γ-Aminobutyronitriles
    Synlett 2018, 29, 530–536.
    Most Read Synlett Articles
    https://doi.org/10.1055/s-0036-1591722

2017

  1. Ikawa, Takashi;* Masuda, Shigeaki; Nakajima, Hiroki; Akai, Shuji*
    2-(Trimethylsilyl)phenyl Trimethylsilyl Ethers as Stable and Readily Accessible Benzyne Precursors
    J. Org. Chem. 2017, 82, 4242–4253.
    https://doi.org/10.1021/acs.joc.7b00238
  2. Kawanishi, Shinji; Sugiyama, Koji; Oki, Yasuhiro; Ikawa, Takashi; Akai, Shuji*
    Preparation of optically active cycloalkenes bearing all-carbon quaternary stereogenic centres via lipase-oxovanadium combo-catalyzed dynamic kinetic resolution
    Green Chem. 2017, 19, 411–417.
    https://doi.org/10.1039/C6GC01995A

2016

  1. Ikawa, Takashi;* Masuda, Shigeaki; Takagi, Akira; Akai, Shuji*
    1,3- and 1,4-Benzdiyne Equivalents for Regioselective Synthesis of Polycyclic Heterocycles
    Chem. Sci. 2016, 7, 5206–5211.
    https://doi.org/10.1039/C6SC00798H
  2. Sugiyama, Koji; Oki, Yasuhiro; Kawanishi, Shinji; Kato, Katsuya; Ikawa, Takashi; Egi, Masahiro; Akai, Shuji*
    Spatial effects of oxovanadium-immobilized mesoporous silica on racemization of alcohols and application in lipase-catalyzed dynamic kinetic resolution
    Catal. Sci. Technol. 2016, 6, 5023–5030.
    https://doi.org/10.1039/C6CY00257A
  3. Takubo, Keita; Furutsu, Kazunori; Ide, Takafumi; Nemoto, Hiroyuki; Ueda, Yuko; Tsujikawa, Kazutake; Ikawa, Takashi; Yoshimitsu, Takehiko; Akai, Shuji*
    Diversity Oriented Synthesis of Allocolchicinoids with Fluoro and/or Oxygen Substituent(s) on the C-Ring from a Single Common Intermediate
    Eur. J. Org. Chem. 2016, 1562–1576.
    https://doi.org/10.1002/ejoc.201501624

2015

  1. Ikawa, Takashi;* Yamamoto, Rika; Takagi, Akira; Ito, Toyohiro; Shimizu, Kazunori; Goto, Masahiko; Hamashima, Yoshitaka; Akai, Shuji*
    2-[(Neopentyl glycolato)boryl]phenyl Triflates and Halides for Fluoride-Ion-Mediated Generation of Functionalized Benzynes
    Adv. Synth. Cat. 2015, 357, 2287–2300.
    https://doi.org/10.1002/adsc.201500315
  2. Yokozawa, Saori; Ohneda, Noriyuki; Muramatsu, Ken; Okamoto, Tadashi; Odajima, Hiromichi; Ikawa, Takashi; Sugiyama, Jun-ichi; Fujita, Masashi; Sawairi, Taira; Egami, Hiromichi; Hamashima, Yoshitaka; Egi, Masahiro; Akai, Shuji*
    Development of a Highly Efficient Single-Mode Microwave Applicator with a Resonant Cavity and its Application to Continuous Flow Syntheses
    RSC Adv. 2015, 5, 10204–10210.
    https://doi.org/10.1039/C4RA12428F
  3. Ikawa, Takashi;* Kaneko, Hideki; Masuda, Shigeaki; Ishitsubo, Erika; Tokiwa, Hiroaki; Akai, Shuji*
    Trifluoromethanesulfonyloxy-Group-Directed Regioselective (3+2) Cycloadditions of Benzynes for the Synthesis of Functio alized Benzo-fused Heterocycles
    Org. Biomol. Chem. 2015, 13, 526–529.
    https://doi.org/10.1039/C4OB01627K

2014

  1. Ikawa, Takashi;* Urata, Hirohito; Fukumoto, Yutaka; Sumii, Yuta; Nishiyama, Tsuyoshi; Akai, Shuji*
    Concise Synthesis of Multisubstituted Isoquinolines from Pyridines by Regioselective Diels–Alder Reactions of 2-Silyl-3,4-Pyridynes
    Chem. Eur. J. 2014, 20, 16228–16232.
    https://doi.org/10.1002/chem.201404633
  2. Ikawa, Takashi;* Masuda, Shigeaki; Nishiyama, Tsuyoshi; Takagi, Akira; Akai, Shuji*
    Synthesis of Fluorinated Aromatic Compounds by One-pot Benzyne Formation/Nucleophilic Fluorination
    Aust. J. Chem. 2014, 67, 475–480.
    https://doi.org/10.1071/CH13548

2013

  1. Takagi, Akira; Ikawa, Takashi;* Saito, Kozumo; Masuda, Shigeaki; Ito, Toyohiro; Akai, Shuji*
    ortho-Selective nucleophilic addition of amines to 3-borylbenzynes: Synthesis of multisubstituted anilines by triple role of boryl group
    Org. Biomol. Chem. 2013, 11, 8145–8150.
    DOI
    https://doi.org/10.1039/C3OB41787E
  2. Todoroki, Kenichiro;* Ishii, Yasuhiro; Toyoda, Koji; Ikawa, Takashi; Min, Jun Zhe; Inoue, Koichi; Akai, Shuji; Toyo’oka, Toshimasa*
    Dress-Up Chiral Columns for the Enantioseparation of Amino Acids Based on Fluorous Separation
    Anal. Bioanal. Chem. 2013, 405, 8121–8129.
    https://doi.org/10.1007/s00216-013-7207-4
  3. Takagi, Akira; Ikawa, Takashi; Kurita, Yurio; Saito, Kozumo; Azechi, Kenji; Egi, Masahiro; Itoh, Yuji; Tokiwa, Hiroaki; Kita, Yasuyuki; Akai, Shuji*
    Generation of 3-Borylbenzynes, Their Regioselective Diels-Alder Reactions, and Theoretical Analysis
    Tetrahedron 2013, 69, 4338–4352.
    https://doi.org/10.1016/j.tet.2013.03.016
  4. フロー有機合成反応に用いる共振器型マイクロ波照射装置の開発
    杉山 順一, 横澤 早織, 大根田 訓之, 井川 貴詞, 江木 正浩, 赤井周司
    信学技報 113(12) 9-14 2013年4月
  5. Ikawa, Takashi; Takagi, Akira; Goto, Masahiko; Aoyama, Yuya; Ishikawa, Yoshinobu; Itoh, Yuji; Fujii, Satoshi; Tokiwa, Hiroaki;* Akai, Shuji*
    Regiocomplementary Cycloaddition Reactions of Boryl- and Silylbenzynes with 1,3-Dipoles: Selective Synthesis of Benzo-Fused Azole Derivatives
    J. Org. Chem. 2013, 78, 2965−2983.
    https://doi.org/10.1021/jo302802b
  6. Komaki, Ryoichi;* Ikawa, Takashi; Saito, Kozumo; Hattori, Kazuyo; Ishikawa, Natsuyo; Fukawa, Hidemichi; Egi, Masahiro; Akai, Shuji*
    Discovery of Aromatic Components with Excellent Fragrance Properties and Biological Activities: β-Ionols with Antimelanogenetic Effects and Their Asymmetric Syntheses
    Chem. Pharm. Bull. 2013, 61, 310–314.
    https://doi.org/10.1248/cpb.c12-00916

2012

  1. Ikawa, Takashi; Saito, Kozumo; Akai, Shuji*
    Palladium-Catalyzed One-Pot Cross-Coupling of Phenols Using Nonafluorobutanesulfonyl Fluoride
    Synlett 2012, 23, 2241–2246.
    https://doi.org/10.1055/s-0032-1317076
  2. Ikawa, Takashi; Fujita, Yuki; Mizusaki, Tomoteru; Betsuin, Sae; Takamatsu, Haruki; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao*
    Selective N-Alkylation of Amines Using Nitriles under Hydrogenation Conditions: Facile Synthesis of Secondary and Tertiary Amines
    Org. Biomol. Chem. 2012, 10, 293–304.
    https://doi.org/10.1039/C1OB06303K

2011

  1. Ikawa, Takashi; Nishiyama, Tsuyoshi; Shigeta, Takashi; Mohri, Shinya; Morita, Shinsuke; Takayanagi, Sho-ichi; Terauchi, Yuki; Morikawa, Yuki; Takagi, Akira; Ishikawa, Yoshinobu; Fujii, Satoshi; Kita, Yasuyuki; Akai, Shuji*
    ortho-Selective Nucleophilic Addition of Primary Amines to Silylbenzynes: Synthesis of 2-Silylanilines
    Angew. Chem. Int. Ed. 2011, 50, 5674–5677.
    https://doi.org/10.1002/anie.201100360
  2. Ikawa, Takashi; Nishiyama, Tsuyoshi; Nosaki, Toshifumi; Takagi, Akira, Akai, Shuji*
    A Domino Process for Benzyne Preparation: Dual Activation of o-(Trimethylsilyl)phenols by Nonafluorobutanesulfonyl Fluoride
    Org. Lett. 2011, 13, 1730–1733.
    https://doi.org/10.1021/ol200252c

2010

  1. Ikawa, Takashi; Takagi, Akira; Kurita, Yurio; Saito, Kozumo; Azechi, Kenji; Egi, Masahiro; Kakiguchi, Keisuke; Kita, Yasuyuki; Akai, Shuji*
    Preparation of Borylbenzynes and Their Regioselective Diels–Alder Reaction: Synthesis of Functionalized Arylboronates
    Angew. Chem. Int. Ed. 2010, 49, 5563–5566 (VIP: Very Important Paper).
    https://doi.org/10.1002/anie.201002191

2009

  1. Mori, Shigeki; Ohkubo, Tomoyuki; Ikawa, Takashi; Kume, Akira; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao*
    Pd(0)-Polyethyleneimine Complex as a Partial Hydrogenation Catalyst of Alkynes to Alkenes
    J. Mol. Catal. A: Chem. 2009, 307, 77–87.
    https://doi.org/10.1016/j.molcata.2009.03.013
  2. Maegawa, Tomohiro; Fujiwara, Yuta; Ikawa, Takashi; Hisashi, Hideo; Monguchi, Yasunari; Sajiki, Hironao*
    Novel Deprotection Method of Fmoc Group Under Neutral Hydrogenation Conditions
    Amino Acids, 2009, 36, 493–499.
    https://doi.org/10.1007/s00726-008-0109-7

2008

  1. Monguchi, Yasunari; Kitamoto, Katsunori; Ikawa, Takashi; Maegawa, Tomohiro; Sajiki, Hironao*
    Evaluation of Aromatic Amination Catalyzed by Palladium on Carbon: a Practical Synthesis of Triarylamines
    Adv. Synth. Catal. 2008, 350, 2767–2777.
    https://doi.org/10.1002/adsc.200800417
  2. Akai, Shuji;* Ikawa, Takashi; Takayanagi, Sho-ichi; Morikawa, Yuki; Mohri, Shinya; Tsubakiyama, Masaya; Egi, Masahiro; Wada, Yasufumi; Kita, Yasuyuki
    Synthesis of Biaryl Compounds through Three-Component Assembly: Ambidentate Effect of the tert-Butyldimethylsilyl Group for Regioselective Diels–Alder and Hiyama Coupling Reactions
    Angew. Chem. Int. Ed. 2008, 47, 7673–7676.
    https://doi.org/10.1002/anie.200803011
  3. Sajiki, Hironao;* Mori, Shigeki; Ohkubo, Tomoyuki; Ikawa, Takashi; Kume, Akira; Maegawa, Tomohiro; Monguchi, Yasunari
    Partial Hydrogenation of Alkynes to cis-Olefins by Using a Novel Pd0-Polyethyleneimine Catalyst
    Chem. Eur. J. 2008, 14, 5109–5111.
    https://doi.org/10.1002/chem.200800535

2007

  1. Kitamura, Yoshiaki; Tanaka, Asami; Sato, Mutsumi; Oono, Keiji; Ikawa, Takashi; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao*
    Development of a Practical and Scalable Preparation Using Sonication of Pd/Fibroin Catalyst for Chemoselective Hydrogenation
    Synth. Commun. 2007, 37, 4381–4388.
    https://doi.org/10.1080/00397910701577612
  2. Ikawa, Takashi; Barder, Timothy E.; Biscoe, Mark R.; Buchwald, Stephen L.*
    Pd-Catalyzed Amidations of Aryl Chlorides Using Monodentate Biaryl Phosphine Ligands: A Kinetic, Computational, and Synthetic Investigation
    J. Am. Chem. Soc. 2007, 129, 13001–13007.
    https://doi.org/10.1021/ja0717414
  3. Mori, Akinori; Mizusaki, Tomoteru; Ikawa, Takashi; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao*
    Mechanistic Study on a Pd/C-Catalyzed Reduction of Aryl Sulfonates Using Mg-MeOH-NH4OAc System
    Chem. Eur. J. 2007, 13, 1432–1441.
    https://doi.org/10.1002/chem.200601184
  4. Mori, Akinori; Mizusaki, Tomoteru; Ikawa, Takashi; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao*
    Palladium on Carbon-Diethylamine-Mediated Hydrodeoxygenation of Phenol Derivatives Under Mild Conditions
    Tetrahedron 2007, 63, 1270–1280.
    https://doi.org/10.1016/j.tet.2006.11.060

2006

  1. Anderson, Kevin W.; Tundel, Rachel E.; Ikawa, Takashi; Altman, Ryan A.; Buchwald, Stephen L.*
    Monodentate Phosphines Provide Highly Active Catalysts for Pd-Catalyzed C-N Bond-Forming Reactions of Heteroaromatic Halides/Amines and (H)N-Heterocycles
    Angew. Chem. Int. Ed. 2006, 45, 6523–652.
      https://doi.org/10.1002/anie.200601612
  2. Anderson, Kevin W.; Ikawa, Takashi; Tundel, Rachel E.; Buchwald, Stephen L.*
    The Selective Reaction of Aryl Halides with KOH: Synthesis of Phenols, Aromatic Ethers, and Benzofurans
    J. Am. Chem. Soc. 2006, 128, 10694–10695.
    https://doi.org/10.1021/ja0639719
  3. Sajiki, Hironao;* Mori, Akinori; Mizusaki, Tomoteru; Ikawa, Takashi; Maegawa, Tomohiro; Hirota, Kosaku
    Pd/C-Catalyzed Deoxygenation of Phenol Derivatives Using Mg Metal and MeOH in the Presence of NH4OAc
    Org. Lett. 2006, 8, 987–990.
    https://doi.org/10.1021/ol060045q

2005

  1. Sajiki, Hironao;* Ikawa, Takashi; Hirota, Kosaku*
    A Practical and One-Pot Procedure for the Synthesis of 3-Amino-2-cyclohexen-1-one from 3-Aminophenol
    Org. Process Res. Dev. 2005, 9, 219–220.
    https://doi.org/10.1021/op0497761
  2. Ikawa, Takashi; Sajiki, Hironao;* Hirota, Kosaku*
    Highly Chemoselective Hydrogenation Method Using Novel Finely Dispersed Palladium Catalyst on Silk-Fibroin: Its Preparation and Activity
    Tetrahedron 2005, 61, 2217–2231.
    https://doi.org/10.1016/j.tet.2004.11.080

2004

  1. Sajiki, Hironao;* Ikawa, Takashi; Hirota, Kosaku*
    Reductive and Catalytic Monoalkylation of Primary Amines Using Nitriles as an Alkylating Reagent
    Org. Lett. 2004, 6, 4977–4980.
    https://doi.org/10.1021/ol047871o
  2. Ikawa, Takashi; Hattori, Kazuyuki; Sajiki, Hironao;* Hirota, Kosaku*
    Solvent-Modulated Pd/C-Catalyzed Deprotection of Silyl Ethers and Chemoselective Hydrogenation
    Tetrahedron 2004, 60, 6901–6911.
    https://doi.org/10.1016/j.tet.2004.05.098
  3. Ikawa, Takashi; Sajiki, Hironao;* Hirota, Kosaku*
    Unexpected Deprotection of Silyl and THP Ethers Induced by Serious Disparity in the Quality of Pd/C Catalysts and Elucidation of the Mechanism
    Tetrahedron 2004, 60, 6189–6195.
    https://doi.org/10.1016/j.tet.2004.05.040

2003

  1. Sajiki, Hironao;* Ikawa, Takashi; Hirota, Kosaku*
    Markedly Chemoselective Hydrogenation with Retention of Benzyl Ester and N-Cbz Functions Using a Heterogeneous Pd-Fibroin Catalyst
    Tetrahedron Lett. 2003, 44, 8437–8439.
    https://doi.org/10.1016/j.tetlet.2003.09.137
  2. Sajiki, Hironao;* Ikawa, Takashi; Hirota, Kosaku*
    Significant Supplier-Dependent Disparity in Catalyst Activity of Commercial Pd/C Toward the Cleavage of Triethylsilyl Ether
    Tetrahedron Lett. 2003, 44, 7407–7410.
    https://doi.org/10.1016/j.tetlet.2003.08.045
  3. Sajiki, Hironao;* Ikawa, Takashi; Hattori, Kazuyuki; Hirota, Kosaku*
    A Remarkable Solvent Effect Toward the Pd/C-Catalyzed Cleavage of Silyl Ethers
    Chem. Commun. 2003, 654–655.
    https://doi.org/10.1039/B211313A
  4. Sajiki, Hironao;* Ikawa, Takashi; Yamada, Hiromi; Tsubouchi, Kozo; Hirota, Kosaku*
    Preparation of Silk Fibroin-Supported Pd(0) Catalyst for Chemoselective Hydrogenation: Reduction of Palladium(II) Acetate by Methanol on the Protein
    Tetrahedron Lett. 2003, 44, 171–174.
    https://doi.org/10.1016/S0040-4039(02)02472-3