2026

  1. Naoya Ito; Naoya Sakurada; Tatsunori Iwamura; Takashi Ikawa; Hironao Sajiki
    Methanation of Metal Carbonates with Mechano-Energy Using H2O as a Reducing Agent
    Chemical Engineering Journal Advances 2026, in press.
    DOI: https://doi.org/10.1016/j.ceja.2026.101221
    ▶Published version
    This article is available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
  2. Sakurada, Naoya; Tomoto, Sae; Oka, Naoki; Ichikawa, Tomohiro; Shigeta, Takashi; Sajik, Hironao; Ikawa, Takashi
    Pt/C-Catalyzed Deuteration of Polycyclic Aromatic Hydrocarbons with Suppressed Arene Hydrogenation
    European Journal of Organic Chemistry 2026, in press.
    DOI: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.70562
    ▶Published version PDF
    This article is distributed under the terms of the Creative Commons Attribution 4.0 International License. 
  3. Sakurada, Naoya; Kawahara, Chinatsu; Fujii, Akiko; Ikawa, Takashi; Sajiki, Hironao
    Low-Loading Pd/C-Catalyzed Continuous-Flow Chemoselective Hydrogenation of Cinnamaldehyde Derivatives for Scalable Production
    Organic Process Research & Development 2026, in press.
    DOI: https://pubs.acs.org/doi/10.1021/acs.oprd.5c00522

2025

  1. Naohito Tomita, Hironao Sajiki, Takashi Ikawa
    Synthesis of cyclic carbonates via silver-catalysed fixation of CO2 to propargyl alcohols under mechanochemical conditions
    RSC Mechanochemistry, 2025, 2(6), 809-812
    ▶Published version PDF
    This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
  2. Akiko Fujii, Kwihwan Kobayashi, Tomoki Hyodo, Tsuyoshi Yamada, Takashi Ikawa, Hironao Sajiki
    Synthesis of Functionalized Cyclic Ethers via Gold-Catalyzed Cyclization and Rearrangement
    Adv. Synth. Catal., e70012
    https://doi.org/10.1002/adsc.70012
  3. Naoya Sakurada, Kanon Kawai, Yuka Abe, Kwihwan Kobayashi, Shinya Mine, Noriko Miyamoto, Tsuyoshi Yamada, Takashi Ikawa, Hironao Sajiki
    Durable Heterogeneous Pd-PNP Pincer Complex for Carbon-Carbon Bond Formation in Continuous-Flow Systems
    ChemSusChem, e202501205
    https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cssc.202501205
    フロー式 Mizoroki–Heck 反応で 14 日連続の高変換を実証 ― PNPリガンドと塩基最適化でPd触媒活性の維持に成功 ― | 岐阜薬科大学 創薬化学大講座 アドバンストケミストリー研究室 （解説）
    【研究成果】フロー式 Mizoroki-Heck 反応で 14 日連続の高変換を実証 ― PNPリガンドと塩基最適化でPd触媒活性の維持に成功 ―｜岐阜薬科大学（大学Webサイト）
  4. Akiko Fujii, Tomoki Hyodo, Tsuyoshi Yamada, Takashi Ikawa, Hironao Sajiki
    Silver-Catalyzed Synthesis of Isoquinolones via Oxazole Ring OpeningClick to copy article link
    J. Org. Chem. 2025, 90, 37, 13279–13284.
    https://pubs.acs.org/doi/10.1021/acs.joc.5c01059
  5. Sakurada, Naoya; Sasaki, Daiki; Ono, Manato; Yamada, Tsuyoshi; Ikawa, Takashi;* Sajiki, Hironao*
    Development of Site- and Stereoselective Continuous Flow Deuterium Labelling Method for Carbohydrates Using High Dispersion Effect towards Ru/C of Hydrogen Flow
    Reaction Chemistry & Engineering 2025,10, 777-781.
    https://doi.org/10.1039/D5RE00026B
    位置・立体選択的に糖を重水素化するフロー合成法を確立 ― Ru/C 触媒カートリッジで 150 時間以上の連続運転を実証 ― （解説）
    【研究成果】位置・立体選択的に糖を重水素化するフロー合成法を確立 ― Ru/C 触媒カートリッジで 150 時間以上の連続運転を実証 ―｜岐阜薬科大学　（大学Webサイト）
    位置・立体選択的に糖を重水素化するフロー合成法を確立 ― Ru/C触媒カートリッジで150時間以上の連続運転を実証 ― | Chem-Station (ケムステ)
  6. Yuka Abe, Tsuyoshi Yamada,* Takuhei Yamamoto, Yukihiro Esaka, Takashi Ikawa, Hironao Sajiki*
    Electrochemically assisted deprotection of acetals, ketals, and dithioacetals under neutral conditions
    Green Chemistry 2025, 27, 5464-5470.
    https://doi.org/10.1039/D4GC06348A
    Selected as a Cover Picture
  7. Shogo Moriyama , Yuto Emi , Toshifumi Nosaki , Yuki Morikawa , Takashi Shigeta  , Akira Takagi , Masahiro Egi  , Takashi Ikawa , Yoshinari Sawama  , Shuji Akai
    Total synthesis of aloin via regioselective Diels–Alder reactions connecting two 3-silylbenzynes and 2-stannylfuran
    Synlett 2025, 36(10), 1413-1417.
    https://doi.org/ 10.1055/a-2542-3481
  8. Hikaru Tanaka, Takashi Ikawa, Hironao Sajiki, Masanori Tachikawa, Taro Udagawa*
    Theoretical analysis of the reaction mechanism of D2 gas generation using a Pd/C catalyst
    Catalysis Science & Technology 2025, 15, 1434-1438.
    https://doi.org/10.1039/D4CY01537A

2024

  1. Sakurada, Naoya; Kobayashi, Kwihwan; Abe; Yuka; Niwa, Kosuke; Yokoyama, Takashi; Yamada, Tsuyoshi; Ikawa, Takashi; Sajiki, Hironao
    Stable and Versatile Pd Precursors for the Preparation of Robust Pd Catalysts under Continuous-Flow
    ChemSusChem 2024, e202401859.
    https://doi.org/10.1002/cssc.202401859
    Selected as a Cover Picture
    多様な材料に効率的にパラジウムを担持可能な前駆体（Pd-80）の開発と、持続的フロー触媒の創製（解説）
    【研究成果】多様な材料に効率的にパラジウムを担持可能な前駆体（Pd-80）の開発と、持続的フロー触媒の創製（大学Webサイト）
  2. Sakurada, Naoya; Kitazono, Takanori; Ikawa, Takashi; Yamada, Tsuyoshi; Sajiki, Hironao*
    Pt/CB-Catalyzed Chemoselective Hydrogenation Using in situ-Generated Hydrogen by Microwave Mediated Dehydrogenation of Methylcyclohexane under Continuous-Flow Conditions
    Catalysts 2024, 14, 384.
    https://doi.org/10.3390/catal14060384
    Selected as a Hilight paper on the main page of Catalysts
  3. Yamada, Tsuyoshi; Fujii Akiko; Furugen, Chikara; Kobayashi, Kwihwan; Hyodo, Tomoki; Ikawa, Takashi; Sajiki, Hironao*
    Gold-Catalyzed Synthesis of Ortho-Quinone Methide Analogues as Reactive Synthetic Precursors
    Adv. Synth. Catal. 2024, 366, 2270–2276.
    https://doi.org/10.1002/adsc.202400428
    Selected as a Front Cover Picture (Adv. Synth. Catal. 2024, 366, 2141).
  4. Ishida, Moeka; Adachi, Rina; Kobayashi, Kazuki; Yamamoto, Yukiko; Kawahara, Chinatsu; Yamada, Tsuyoshi; Aoyama, Hiroshi; Kanomata, Kyohei; Akai, Shuji; Lam, Patrick Y. S.; Sajiki, Hironao; Ikawa, Takashi*
    First atroposelective Chan–Lam coupling for the synthesis of C–N linked biaryls
    Chem. Commun. 2024, 60, 621–768.
    https://doi.org/10.1039/D3CC05447K
    Selected as an inside front cover
    【研究成果】世界初のアトロプ選択的Chan-Lamカップリングを開発しました！｜岐阜薬科大学

2023

  1. Maekawa, Kazuki; Ishizawa, Michiyasu; Ikawa, Takashi; Sajiki, Hironao; Matsumoto, Taro; Tokiwa, Hiroaki; Makishima, Makoto; Yamada, Sachiko*
    Syntheses of 25-Adamantyl-25-alkyl-1α,25-dihydroxyvitamin D3 Derivatives and Structure-Function Studies of ntagonistic and Agonistic Active Vitamin D Analogs
    Biomolecules 2023, 13, 1082.
    https://doi.org/10.3390/biom13071082
  2. Yamada, Tsuyoshi; Teranishi, Wataru; Sakurada, Naoya; Ootori, Seiya; Abe, Yuka; Matsuo, Tomohiro; Morii, Yasuharu; Yoshimura, Masatoshi; Yoshimura, Takeo; Ikawa, Takashi; Sajiki, Hironao*
    Microwave-assisted C–C bond formation of diarylacetylenes and aromatic hydrocarbons on carbon beads under continuous-flow conditions
    Commun. Chem. 2023, 6, 78.
    https://doi.org/10.1038/s42004-023-00880-y
    【研究成果】マイクロ波のエネルギーを利用して、クリーンな多環芳香族化合物の連続フロー合成法を開発！｜岐阜薬科大学

2022

  1. Horino, Satoshi; Nishio, Tomoya; Kawanishi, Shinji; Oki, Shinya; Nishihara, Kouichi; Ikawa, Takashi; Kanomata, Kyohei; Wagner, Karla; Gröger, Harald; Akai, Shuji
    Enantiodivergent Chemoenzymatic Dynamic Kinetic Resolution: Conversion of Racemic Propargyl Alcohols into Both Enantiomers
    Chem. Eur. J. 2022, 28, e202202437.
    https://doi.org/10.1002/chem.202202437
  2. Park, Kwihwan; Furusato, Shinichi; Furugen, Chikara; Ikawa, Takashi; Yamada, Tsuyoshi; Sajiki, Hironao
    Highly Selective Synthesis of cis-2,2,4,4-Tetramethylcyclobutane-1,3-diol via Solvent-Free Hydrogenation and Isomerization
    Asian J. Chem. 2022, 11, e202200263.
    https://doi.org/10.1002/ajoc.202200263
  3. Oka, Naoki; Yamada, Tsuyoshi; Sajiki, Hironao; Akai, Shuji;* Ikawa, Takashi*
    Aryl Boronic Esters Are Stable on Silica Gel and Reactive under Suzuki–Miyaura Coupling Conditions
    Org. Lett. 2022, 24, 3510−3514.
    https://pubs.acs.org/doi/10.1021/acs.orglett.2c01174
    【研究成果】誰でも簡単に扱えるボロン酸誘導体を開発しました！｜岐阜薬科大学
    Selected as a Supplementary Cover Art
    Most Read Articles in 30 days (Ranked in No.1). 2022/07/11
    Most Read Articles in 12 months (Ranked in No.1).2022/07/11-2022/12/18
    The most read #OrgLett articles for 2022.
    Highlighted in Chem-Station (https://www.chem-station.com/blog/2022/07/smc.html)
    Highlighted in Faculty Opinions
    (https://doi.org/10.3410/f.742220886.793594018)
    Highlighted in Synfacts
    SYNFACTS Contributors: Oestreich, Martin; Klare, Hendrik F. T.; Finck, Lucie
    Take Et instead of Me: Preparation and Application of a Novel Class of Stable Arylboronic Esters
    Synfacts 2022, 18(08), 0867. Selected as “Synfact of the month”
    https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0041-1738238
    Highlighted in Organic Process Reseach & Development, 2022, 26, 3181–3189.
    “ARYLBORONIC ESTERS ARE STABLE ON SILICA GEL AND REACTIVE UNDER SUZUKI−MIYAURA COUPLING CONDITIONS”
    Highlighted in Organic Chemistry Portal (https://www.organic-chemistry.org/abstracts/lit8/448.shtm).
    Attention Score 112 (2022/12/18)
    In the top 5% of all research outputs scored by Altmetric
    One of the highest-scoring outputs from this source (#8 of 14,044)
    High Attention Score compared to outputs of the same age (higher than 97% of its contemporaries)
    High Attention Score compared to outputs of the same age and source (#1 of 236 output, higher than 99% of its contemporaties)
    日本の研究.com
    https://research-er.jp/articles/view/110906
    The most cited tweet from 2022 on @Boron_chemistry
  4. Park, Kwihwan;* Oka, Naoki; Sawama, Yoshinari; Ikawa, Takashi; Yamada, Tsuyoshi; Sajiki, Hironao
    Platinum on carbon-catalysed site-selective H–D exchange reaction of allylic alcohols using alkyl amines as a hydrogen source
    Org. Chem. Front. 2022, 9, 1986–1991.
    https://doi.org/10.1039/D2QO00177B
  5. Yamada, Tsuyoshi* Fujii, Akiko; Park, Kwihwan; Furugen, Chikara; Takagi, Akira; Ikawa, Takashi; Sajiki Hironao*
    Catalytic Intramolecular Cyclization of Alkynyl Cyclic Acetals via Chemoselective Activation Leading to Phenanthrene Core
    Bull. Chem. Soc. Jpn. 2022, 95, 735−742.
    https://doi.org/10.1246/bcsj.20220036

2021

  1. Ikawa, Takashi;* Yamamoto, Yuta; Heguri, Akito; Fukumoto, Yutaka; Murakami, Tomonari; Takagi, Akira; Masuda, Yuto; Yahata, Kenzo; Yahata, Kenzo; Aoyama, Hiroshi; Shigeta, Yasuteru; Tokiwa,Hiroaki;* Akai; Shuji*
    Could London Dispersion Force Control Regioselective (2+2) Cyclodimerizations of Benzynes? YES: Application to the Synthesis of Helical Biphenylenes
    J. Am. Chem. Soc. 2021, 143, 10853−10859.
    https://pubs.acs.org/doi/10.1021/jacs.1c05434
    【研究成果】"弱い引力"を利用して『らせん分子』の合成に成功！｜岐阜薬科大学
    Selected as a Supplementary Cover Art
    Highlighted in Chem-Station (https://www.chem-station.com/blog/2021/08/london.html)
    Highlighted in Synfacts
    SYNFACTS Contributors: Swager, Timothy M.; Chen, Michelle
    May the 'London Dispersion Force' Be with You
    Synfacts 2021, 17(09), 0981.
    https://doi.org/10.1055/s-0040-1720812
    Highlighted in ファルマシア Editor’s Eye
    ロンドン分散力による分子構造の制御
    ファルマシアVol. 57, No. 12, 2021, 1075.
  2. Hori, Shuhei; Ishida, Sho; Itoh, Go; Egi, Masahiro; Yahata, Kenzo; Ikawa, Takashi; Akai, Shuji*
    Synthetic studies on viridin skeleton through regio- and stereoselective unctionalization of the AE-ring moiety
    Synlett 2021, 32, 1187−1191.
    https://doi.org/10.1055/a-1527-3781
  3. Saito, Kazuyuki; Zhou, Wang; Sato, Shohei; Takubo, Keita; Furutsu, Kazunori; Mohamed, Ahmed A.B.; Purwati, Euis Maras; Ikawa, Takashi; Akai, Shuji*
    Regio-Complementary Preparation of 6- and 7-Fluoro-1,2,3,4-tetrahydroquinolines via the Cyclization of Catecholamines Followed by Deoxyfluorination
    Heterocycles 2021, 103, 902−917.
    https://doi.org/10.3987/COM-20-S(K)56
  4. Tsuchimochi, Izuru; Hori, Shuhei; Takeuchi, Yasuo; Egi, Masahiro; Satoh, Tomo-o; Kanomata, Kyohei; Ikawa, Takashi; Akai, Shuji*
    Four-step one-pot catalytic asymmetric synthesis of multisubstituted tricyclic compounds: Lipase-catalyzed dynamic kinetic resolution followed by an intramolecular Diels–Alder reaction
    Synlett 2021, 32, 822-828.
    https://doi.org/10.1055/a-1344-8713

2020

  1. Ikawa, Takashi;* JingKai, Sun; Takagi, Akira; Akai, Shuji*
    One-Pot Generation of Functionalized Benzynes from Commercially Available 2-Hydroxyphenylboronic Acids
    J. Org. Chem. 2020, 85, 3383−3392.
    https://pubs.acs.org/doi/10.1021/acs.joc.9b03169
  2. Ikawa, Takashi;* Masuda, Shigeaki; Akai, Shuji*
    One-Pot Generation of Benzynes from Phenols: Formation of Primary Anilines by the Deoxyamination of Phenols
    Chem. Eur. J. 2020, 26, 4320–4332.
    Featured in Org. Chem. Highlights: Substituted Benzenes
    https://www.organic-chemistry.org/Highlights/2020/12October.shtm
    https://doi.org/10.1002/chem.201904987

2018

  1. Ikawa, Takashi;* Masuda, Shigeaki; Akai, Shuji*
    Microflow Fluorinations of Benzynes: Efficient Synthesis of Fluoroaromatic Compounds
    Chem. Pharm. Bull. 2018, 66, 1153–1164.
    Highlighted Paper selected by Editor-in-Chief
    https://doi.org/10.1248/cpb.c18-00578
  2. Kaneko, Hideki; Ikawa, Takashi;* Yamamoto, Yuta; Arulmozhiraja, Sundaram; Tokiwa, Hiroaki; Akai, Shuji*
    3-(Triflyloxy)benzynes Enable the Regiocontrolled Cycloaddition of Cyclic Ureas to Synthesize 1,4-Benzodiazepine Derivatives
    Synlett 2018, 29, 943–948.
    https://doi.org/10.1055/s-0036-1591924
  3. Iwao, Yasunori;* Tomiguchi, Izumi; Domura, Ayaka; Mantaira, Yusuke; Minami, Akira; Suzuki, Takashi; Ikawa, Takashi; Kimura, Shin-ichiro; Itai, Shigeru
    Inflamed site-specific drug delivery system based on the interaction of human serum albumin nanoparticles with myeloperoxidase in a murine model of experimental colitis.
    Eur. J. Pharm. Biopharm. 2018, 125, 141–147.
    https://doi.org/10.1016/j.ejpb.2018.01.016
  4. Ikawa, Takashi;* Sumii, Yuta; Wang, Ding; Emi, Yuto; Takagi, Akira; Masuda, Shigeaki; Akai, Shuji*
    Synthesis of Optically Active 2,3-Disubstituted Indoline Derivatives via Cycloaddition Reactions between Benzynes and α,β-Unsaturated-γ-Aminobutyronitriles
    Synlett 2018, 29, 530–536.
    Most Read Synlett Articles
    https://doi.org/10.1055/s-0036-1591722

2017

  1. Ikawa, Takashi;* Masuda, Shigeaki; Nakajima, Hiroki; Akai, Shuji*
    2-(Trimethylsilyl)phenyl Trimethylsilyl Ethers as Stable and Readily Accessible Benzyne Precursors
    J. Org. Chem. 2017, 82, 4242–4253.
    https://doi.org/10.1021/acs.joc.7b00238
  2. Kawanishi, Shinji; Sugiyama, Koji; Oki, Yasuhiro; Ikawa, Takashi; Akai, Shuji*
    Preparation of optically active cycloalkenes bearing all-carbon quaternary stereogenic centres via lipase-oxovanadium combo-catalyzed dynamic kinetic resolution
    Green Chem. 2017, 19, 411–417.
    https://doi.org/10.1039/C6GC01995A

2016

  1. Ikawa, Takashi;* Masuda, Shigeaki; Takagi, Akira; Akai, Shuji*
    1,3- and 1,4-Benzdiyne Equivalents for Regioselective Synthesis of Polycyclic Heterocycles
    Chem. Sci. 2016, 7, 5206–5211.
    https://doi.org/10.1039/C6SC00798H
  2. Sugiyama, Koji; Oki, Yasuhiro; Kawanishi, Shinji; Kato, Katsuya; Ikawa, Takashi; Egi, Masahiro; Akai, Shuji*
    Spatial effects of oxovanadium-immobilized mesoporous silica on racemization of alcohols and application in lipase-catalyzed dynamic kinetic resolution
    Catal. Sci. Technol. 2016, 6, 5023–5030.
    https://doi.org/10.1039/C6CY00257A
  3. Takubo, Keita; Furutsu, Kazunori; Ide, Takafumi; Nemoto, Hiroyuki; Ueda, Yuko; Tsujikawa, Kazutake; Ikawa, Takashi; Yoshimitsu, Takehiko; Akai, Shuji*
    Diversity Oriented Synthesis of Allocolchicinoids with Fluoro and/or Oxygen Substituent(s) on the C-Ring from a Single Common Intermediate
    Eur. J. Org. Chem. 2016, 1562–1576.
    https://doi.org/10.1002/ejoc.201501624

2015

  1. Ikawa, Takashi;* Yamamoto, Rika; Takagi, Akira; Ito, Toyohiro; Shimizu, Kazunori; Goto, Masahiko; Hamashima, Yoshitaka; Akai, Shuji*
    2-[(Neopentyl glycolato)boryl]phenyl Triflates and Halides for Fluoride-Ion-Mediated Generation of Functionalized Benzynes
    Adv. Synth. Cat. 2015, 357, 2287–2300.
    https://doi.org/10.1002/adsc.201500315
  2. Yokozawa, Saori; Ohneda, Noriyuki; Muramatsu, Ken; Okamoto, Tadashi; Odajima, Hiromichi; Ikawa, Takashi; Sugiyama, Jun-ichi; Fujita, Masashi; Sawairi, Taira; Egami, Hiromichi; Hamashima, Yoshitaka; Egi, Masahiro; Akai, Shuji*
    Development of a Highly Efficient Single-Mode Microwave Applicator with a Resonant Cavity and its Application to Continuous Flow Syntheses
    RSC Adv. 2015, 5, 10204–10210.
    https://doi.org/10.1039/C4RA12428F
  3. Ikawa, Takashi;* Kaneko, Hideki; Masuda, Shigeaki; Ishitsubo, Erika; Tokiwa, Hiroaki; Akai, Shuji*
    Trifluoromethanesulfonyloxy-Group-Directed Regioselective (3+2) Cycloadditions of Benzynes for the Synthesis of Functio alized Benzo-fused Heterocycles
    Org. Biomol. Chem. 2015, 13, 526–529.
    https://doi.org/10.1039/C4OB01627K

2014

  1. Ikawa, Takashi;* Urata, Hirohito; Fukumoto, Yutaka; Sumii, Yuta; Nishiyama, Tsuyoshi; Akai, Shuji*
    Concise Synthesis of Multisubstituted Isoquinolines from Pyridines by Regioselective Diels–Alder Reactions of 2-Silyl-3,4-Pyridynes
    Chem. Eur. J. 2014, 20, 16228–16232.
    https://doi.org/10.1002/chem.201404633
  2. Ikawa, Takashi;* Masuda, Shigeaki; Nishiyama, Tsuyoshi; Takagi, Akira; Akai, Shuji*
    Synthesis of Fluorinated Aromatic Compounds by One-pot Benzyne Formation/Nucleophilic Fluorination
    Aust. J. Chem. 2014, 67, 475–480.
    https://doi.org/10.1071/CH13548

2013

  1. Takagi, Akira; Ikawa, Takashi;* Saito, Kozumo; Masuda, Shigeaki; Ito, Toyohiro; Akai, Shuji*
    ortho-Selective nucleophilic addition of amines to 3-borylbenzynes: Synthesis of multisubstituted anilines by triple role of boryl group
    Org. Biomol. Chem. 2013, 11, 8145–8150.
    DOI
    https://doi.org/10.1039/C3OB41787E
  2. Todoroki, Kenichiro;* Ishii, Yasuhiro; Toyoda, Koji; Ikawa, Takashi; Min, Jun Zhe; Inoue, Koichi; Akai, Shuji; Toyo’oka, Toshimasa*
    Dress-Up Chiral Columns for the Enantioseparation of Amino Acids Based on Fluorous Separation
    Anal. Bioanal. Chem. 2013, 405, 8121–8129.
    https://doi.org/10.1007/s00216-013-7207-4
  3. Takagi, Akira; Ikawa, Takashi; Kurita, Yurio; Saito, Kozumo; Azechi, Kenji; Egi, Masahiro; Itoh, Yuji; Tokiwa, Hiroaki; Kita, Yasuyuki; Akai, Shuji*
    Generation of 3-Borylbenzynes, Their Regioselective Diels-Alder Reactions, and Theoretical Analysis
    Tetrahedron 2013, 69, 4338–4352.
    https://doi.org/10.1016/j.tet.2013.03.016
  4. フロー有機合成反応に用いる共振器型マイクロ波照射装置の開発
    杉山 順一, 横澤 早織, 大根田 訓之, 井川 貴詞, 江木 正浩, 赤井周司
    信学技報 113(12) 9-14 2013年4月
  5. Ikawa, Takashi; Takagi, Akira; Goto, Masahiko; Aoyama, Yuya; Ishikawa, Yoshinobu; Itoh, Yuji; Fujii, Satoshi; Tokiwa, Hiroaki;* Akai, Shuji*
    Regiocomplementary Cycloaddition Reactions of Boryl- and Silylbenzynes with 1,3-Dipoles: Selective Synthesis of Benzo-Fused Azole Derivatives
    J. Org. Chem. 2013, 78, 2965−2983.
    https://doi.org/10.1021/jo302802b
  6. Komaki, Ryoichi;* Ikawa, Takashi; Saito, Kozumo; Hattori, Kazuyo; Ishikawa, Natsuyo; Fukawa, Hidemichi; Egi, Masahiro; Akai, Shuji*
    Discovery of Aromatic Components with Excellent Fragrance Properties and Biological Activities: β-Ionols with Antimelanogenetic Effects and Their Asymmetric Syntheses
    Chem. Pharm. Bull. 2013, 61, 310–314.
    https://doi.org/10.1248/cpb.c12-00916

2012

  1. Ikawa, Takashi; Saito, Kozumo; Akai, Shuji*
    Palladium-Catalyzed One-Pot Cross-Coupling of Phenols Using Nonafluorobutanesulfonyl Fluoride
    Synlett 2012, 23, 2241–2246.
    https://doi.org/10.1055/s-0032-1317076
  2. Ikawa, Takashi; Fujita, Yuki; Mizusaki, Tomoteru; Betsuin, Sae; Takamatsu, Haruki; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao*
    Selective N-Alkylation of Amines Using Nitriles under Hydrogenation Conditions: Facile Synthesis of Secondary and Tertiary Amines
    Org. Biomol. Chem. 2012, 10, 293–304.
    https://doi.org/10.1039/C1OB06303K

2011

  1. Ikawa, Takashi; Nishiyama, Tsuyoshi; Shigeta, Takashi; Mohri, Shinya; Morita, Shinsuke; Takayanagi, Sho-ichi; Terauchi, Yuki; Morikawa, Yuki; Takagi, Akira; Ishikawa, Yoshinobu; Fujii, Satoshi; Kita, Yasuyuki; Akai, Shuji*
    ortho-Selective Nucleophilic Addition of Primary Amines to Silylbenzynes: Synthesis of 2-Silylanilines
    Angew. Chem. Int. Ed. 2011, 50, 5674–5677.
    https://doi.org/10.1002/anie.201100360
  2. Ikawa, Takashi; Nishiyama, Tsuyoshi; Nosaki, Toshifumi; Takagi, Akira, Akai, Shuji*
    A Domino Process for Benzyne Preparation: Dual Activation of o-(Trimethylsilyl)phenols by Nonafluorobutanesulfonyl Fluoride
    Org. Lett. 2011, 13, 1730–1733.
    https://doi.org/10.1021/ol200252c

2010

  1. Ikawa, Takashi; Takagi, Akira; Kurita, Yurio; Saito, Kozumo; Azechi, Kenji; Egi, Masahiro; Kakiguchi, Keisuke; Kita, Yasuyuki; Akai, Shuji*
    Preparation of Borylbenzynes and Their Regioselective Diels–Alder Reaction: Synthesis of Functionalized Arylboronates
    Angew. Chem. Int. Ed. 2010, 49, 5563–5566 (VIP: Very Important Paper).
    https://doi.org/10.1002/anie.201002191

2009

  1. Mori, Shigeki; Ohkubo, Tomoyuki; Ikawa, Takashi; Kume, Akira; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao*
    Pd(0)-Polyethyleneimine Complex as a Partial Hydrogenation Catalyst of Alkynes to Alkenes
    J. Mol. Catal. A: Chem. 2009, 307, 77–87.
    https://doi.org/10.1016/j.molcata.2009.03.013
  2. Maegawa, Tomohiro; Fujiwara, Yuta; Ikawa, Takashi; Hisashi, Hideo; Monguchi, Yasunari; Sajiki, Hironao*
    Novel Deprotection Method of Fmoc Group Under Neutral Hydrogenation Conditions
    Amino Acids, 2009, 36, 493–499.
    https://doi.org/10.1007/s00726-008-0109-7

2008

  1. Monguchi, Yasunari; Kitamoto, Katsunori; Ikawa, Takashi; Maegawa, Tomohiro; Sajiki, Hironao*
    Evaluation of Aromatic Amination Catalyzed by Palladium on Carbon: a Practical Synthesis of Triarylamines
    Adv. Synth. Catal. 2008, 350, 2767–2777.
    https://doi.org/10.1002/adsc.200800417
  2. Akai, Shuji;* Ikawa, Takashi; Takayanagi, Sho-ichi; Morikawa, Yuki; Mohri, Shinya; Tsubakiyama, Masaya; Egi, Masahiro; Wada, Yasufumi; Kita, Yasuyuki
    Synthesis of Biaryl Compounds through Three-Component Assembly: Ambidentate Effect of the tert-Butyldimethylsilyl Group for Regioselective Diels–Alder and Hiyama Coupling Reactions
    Angew. Chem. Int. Ed. 2008, 47, 7673–7676.
    https://doi.org/10.1002/anie.200803011
  3. Sajiki, Hironao;* Mori, Shigeki; Ohkubo, Tomoyuki; Ikawa, Takashi; Kume, Akira; Maegawa, Tomohiro; Monguchi, Yasunari
    Partial Hydrogenation of Alkynes to cis-Olefins by Using a Novel Pd0-Polyethyleneimine Catalyst
    Chem. Eur. J. 2008, 14, 5109–5111.
    https://doi.org/10.1002/chem.200800535

2007

  1. Kitamura, Yoshiaki; Tanaka, Asami; Sato, Mutsumi; Oono, Keiji; Ikawa, Takashi; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao*
    Development of a Practical and Scalable Preparation Using Sonication of Pd/Fibroin Catalyst for Chemoselective Hydrogenation
    Synth. Commun. 2007, 37, 4381–4388.
    https://doi.org/10.1080/00397910701577612
  2. Ikawa, Takashi; Barder, Timothy E.; Biscoe, Mark R.; Buchwald, Stephen L.*
    Pd-Catalyzed Amidations of Aryl Chlorides Using Monodentate Biaryl Phosphine Ligands: A Kinetic, Computational, and Synthetic Investigation
    J. Am. Chem. Soc. 2007, 129, 13001–13007.
    https://doi.org/10.1021/ja0717414
  3. Mori, Akinori; Mizusaki, Tomoteru; Ikawa, Takashi; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao*
    Mechanistic Study on a Pd/C-Catalyzed Reduction of Aryl Sulfonates Using Mg-MeOH-NH4OAc System
    Chem. Eur. J. 2007, 13, 1432–1441.
    https://doi.org/10.1002/chem.200601184
  4. Mori, Akinori; Mizusaki, Tomoteru; Ikawa, Takashi; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao*
    Palladium on Carbon-Diethylamine-Mediated Hydrodeoxygenation of Phenol Derivatives Under Mild Conditions
    Tetrahedron 2007, 63, 1270–1280.
    https://doi.org/10.1016/j.tet.2006.11.060

2006

  1. Anderson, Kevin W.; Tundel, Rachel E.; Ikawa, Takashi; Altman, Ryan A.; Buchwald, Stephen L.*
    Monodentate Phosphines Provide Highly Active Catalysts for Pd-Catalyzed C-N Bond-Forming Reactions of Heteroaromatic Halides/Amines and (H)N-Heterocycles
    Angew. Chem. Int. Ed. 2006, 45, 6523–652.
      https://doi.org/10.1002/anie.200601612
  2. Anderson, Kevin W.; Ikawa, Takashi; Tundel, Rachel E.; Buchwald, Stephen L.*
    The Selective Reaction of Aryl Halides with KOH: Synthesis of Phenols, Aromatic Ethers, and Benzofurans
    J. Am. Chem. Soc. 2006, 128, 10694–10695.
    https://doi.org/10.1021/ja0639719
  3. Sajiki, Hironao;* Mori, Akinori; Mizusaki, Tomoteru; Ikawa, Takashi; Maegawa, Tomohiro; Hirota, Kosaku
    Pd/C-Catalyzed Deoxygenation of Phenol Derivatives Using Mg Metal and MeOH in the Presence of NH4OAc
    Org. Lett. 2006, 8, 987–990.
    https://doi.org/10.1021/ol060045q

2005

  1. Sajiki, Hironao;* Ikawa, Takashi; Hirota, Kosaku*
    A Practical and One-Pot Procedure for the Synthesis of 3-Amino-2-cyclohexen-1-one from 3-Aminophenol
    Org. Process Res. Dev. 2005, 9, 219–220.
    https://doi.org/10.1021/op0497761
  2. Ikawa, Takashi; Sajiki, Hironao;* Hirota, Kosaku*
    Highly Chemoselective Hydrogenation Method Using Novel Finely Dispersed Palladium Catalyst on Silk-Fibroin: Its Preparation and Activity
    Tetrahedron 2005, 61, 2217–2231.
    https://doi.org/10.1016/j.tet.2004.11.080

2004

  1. Sajiki, Hironao;* Ikawa, Takashi; Hirota, Kosaku*
    Reductive and Catalytic Monoalkylation of Primary Amines Using Nitriles as an Alkylating Reagent
    Org. Lett. 2004, 6, 4977–4980.
    https://doi.org/10.1021/ol047871o
  2. Ikawa, Takashi; Hattori, Kazuyuki; Sajiki, Hironao;* Hirota, Kosaku*
    Solvent-Modulated Pd/C-Catalyzed Deprotection of Silyl Ethers and Chemoselective Hydrogenation
    Tetrahedron 2004, 60, 6901–6911.
    https://doi.org/10.1016/j.tet.2004.05.098
  3. Ikawa, Takashi; Sajiki, Hironao;* Hirota, Kosaku*
    Unexpected Deprotection of Silyl and THP Ethers Induced by Serious Disparity in the Quality of Pd/C Catalysts and Elucidation of the Mechanism
    Tetrahedron 2004, 60, 6189–6195.
    https://doi.org/10.1016/j.tet.2004.05.040

2003

  1. Sajiki, Hironao;* Ikawa, Takashi; Hirota, Kosaku*
    Markedly Chemoselective Hydrogenation with Retention of Benzyl Ester and N-Cbz Functions Using a Heterogeneous Pd-Fibroin Catalyst
    Tetrahedron Lett. 2003, 44, 8437–8439.
    https://doi.org/10.1016/j.tetlet.2003.09.137
  2. Sajiki, Hironao;* Ikawa, Takashi; Hirota, Kosaku*
    Significant Supplier-Dependent Disparity in Catalyst Activity of Commercial Pd/C Toward the Cleavage of Triethylsilyl Ether
    Tetrahedron Lett. 2003, 44, 7407–7410.
    https://doi.org/10.1016/j.tetlet.2003.08.045
  3. Sajiki, Hironao;* Ikawa, Takashi; Hattori, Kazuyuki; Hirota, Kosaku*
    A Remarkable Solvent Effect Toward the Pd/C-Catalyzed Cleavage of Silyl Ethers
    Chem. Commun. 2003, 654–655.
    https://doi.org/10.1039/B211313A
  4. Sajiki, Hironao;* Ikawa, Takashi; Yamada, Hiromi; Tsubouchi, Kozo; Hirota, Kosaku*
    Preparation of Silk Fibroin-Supported Pd(0) Catalyst for Chemoselective Hydrogenation: Reduction of Palladium(II) Acetate by Methanol on the Protein
    Tetrahedron Lett. 2003, 44, 171–174.
    https://doi.org/10.1016/S0040-4039(02)02472-3